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Data from Oral Presentation Identifies Three Novel AAV Capsids with High Retinal Transduction

Additional Data Supports Utility of a Novel Cell Line for Efficient AAV Manufacturing

CAMBRIDGE, Mass., May 19, 2022 – Vedere Bio II, Inc., a company developing transformative, next-generation therapies for vision restoration and preservation, today will present new preclinical data at the 25th Annual Meeting of the American Society of Gene and Cell Therapy (ASGCT) taking place in Washington, D.C., and virtually, May 16-19, 2022.

“These data represent a significant step forward for the field of ocular gene therapy, as we have now identified three novel AAV capsids which provide exceptional retinal transduction, as well as a new cell line that enables the manufacturing of AAV vectors at higher titers and percent-full capsids,” said Gabor Veres, Ph.D., Chief Scientific Officer of Vedere Bio II. “Taken together, these advances not only enhance the probability of success for Vedere’s lead program, but also the ability to build a pipeline and scale the production of high-quality vector preps.”

Data from the ASGCT presentations are summarized below.

Three proprietary AAV capsids are exceptionally efficient at transducing retinal cells following intravitreal (IVT) injection

Oral title: Novel AAV Capsids for Intravitreal Delivery: Identifying and Characterizing Novel AAV Variants in Non-Human Primates (Abstract #1199)

Date/Time/Location: Thursday, May 19, 2022 from 11:15 AM – 11:30 AM in Ballroom A

Session: Novel AAV Capsids for the Brain, Eye, and Kidney
Key results:

  • The inner limiting membrane (ILM), is a physical barrier on the retina that prevents therapeutics, including adeno-associated viruses (AAVs), from reaching the diseased retinal cells through intravitreal injection (IVT).
  • To overcome this barrier, a directed evolution approach was utilized to identify three novel capsids that:
    • Display superior transduction efficiency to retinal cells, transducing all retinal layers in non-human primates
    • Show reduced off-target transduction (Ciliary body)
    • Limit inflammatory response (preclinical assay in non-human primates)
    • Show more efficient manufacturability (>2 fold of parental AAV2 serotype)

New cell line enables the manufacturing of AAV vectors at higher titers and percent-full capsids

Poster title: X-RAP™ Suspension Cell Line and Its Platform: Vedere’s Solution for rAAV Manufacturing (Abstract #416)

Date/Time/Location: Monday, May 16, 2022 from 5:30 PM – 6:30 PM in Hall D

Session: Vector Product Engineering, Development or Manufacturing I

Key results:

  • Manufacturing AAV vectors at high titers and percent-full capsids is essential for both commercial viability as well as clinical success (given regulatory requirements).
  • Vedere successfully developed a suspension cell line (X-RAP™), which along with demonstrating zero cell aggregation in high density cultures, consumes less nutrients, quintuples the percent-full capsids and has a titer ~1.8x greater than a commercially available cell line (Gibco™ Viral Production Cells) for rAAV production.
  • Performance was consistent across different cell passage stages, in different scales of shake flask and in a 2L bioreactor. Vedere plans to scale production to 50L bioreactors to confirm that performance is consistent for an industrial-scale process.

About Vedere Bio II, Inc.

Vedere Bio II is a privately held, emerging biopharmaceutical company leveraging proprietary optogenetics and photoswitch technologies along with novel AAV capsids to restore vision in all patients with vision loss due to photoreceptor cell death. Comprising a diverse team of pioneering scientists and drug developers, Vedere Bio II is discovering and developing next generation ocular therapies to restore and preserve vision for those patients. The company is headquartered in Cambridge, MA and is funded by Atlas Ventures, Octagon Capital, Mission BioCapital, Samsara BioCapital, the RD Fund and Casdin Capital. For more information, please visit www.vederebio.com or follow Vedere Bio II on Twitter and LinkedIn.

Media Contact:

Marites Coulter
Verge Scientific Communications
mcoulter@vergescientific.com
(415) 819-2214

CAMBRIDGE, Mass., May 2, 2022 – Vedere Bio II, Inc., a company developing transformative, next-generation therapies for vision restoration and preservation, today announced that two data abstracts will be presented at the 25th Annual Meeting of the American Society of Gene and Cell Therapy (ASGCT) taking place in Washington, D.C., or virtually, May 16-19, 2022.

The presentations will showcase four novel, proprietary AAV capsids with high retinal transduction efficiency, as well as a new cell line (X-RAP™) for rAAV manufacturing. These advances enhance the probability of success for Vedere’s lead program and the ability to establish a pipeline with scalable manufacturability.

Details for the oral and poster presentations are as follows.

Oral presentation:

Novel AAV Capsids for Intravitreal Delivery: Identifying and Characterizing Novel AAV Variants in Non-Human Primates (Abstract #1199)

Date/Time/Location: Thursday, May 19, 2022 from 11:15 AM – 11:30 AM in Ballroom A

Session: Novel AAV Capsids for the Brain, Eye, and Kidney

Poster presentation:

X-RAP™ Suspension Cell Line and Its Platform: Vedere’s Solution for rAAV Manufacturing (Abstract #416)

Date/Time/Location: Monday, May 16, 2022 from 5:30 PM – 6:30 PM in Hall D

Session: Vector Product Engineering, Development or Manufacturing I

About Vedere Bio II, Inc.

Vedere Bio II is a privately held, emerging biopharmaceutical company leveraging proprietary optogenetics and photoswitch technologies along with novel AAV capsids to restore vision in all patients with vision loss due to photoreceptor cell death. Comprising a diverse team of pioneering scientists and drug developers, Vedere Bio II is discovering and developing next generation ocular therapies to restore and preserve vision for those patients. The company is headquartered in Cambridge, MA and is funded by Atlas Ventures, Octagon Capital, Mission BioCapital, Samsara BioCapital, the RD Fund and Casdin Capital. For more information, please visit www.vederebio.com or follow Vedere Bio II on Twitter and LinkedIn.

Media Contact:

Marites Coulter
Verge Scientific Communications
mcoulter@vergescientific.com
(415) 819-2214

CAMBRIDGE, Mass., April 26, 2022 – Vedere Bio II, Inc., a company developing transformative, next-generation therapies for vision restoration and preservation, today announced the appointment of Anna-Maria Demetriades, M.D., Ph.D. as Chief Medical Officer. Dr. Demetriades is a board-certified ophthalmologist with over 20 years of experience in clinical ophthalmology and ocular gene therapy research as well as ophthalmic drug development from her time at Genentech.

“We are very excited to have Anna join our leadership team,” said Cyrus Mozayeni, M.D., Chief Executive Officer and President, Vedere Bio II and Atlas Venture Entrepreneur in Residence. “Anna brings a broad range of expertise to Vedere, gained through her leadership on foundational studies in gene therapy and ocular diseases, along with industry experience in clinical development. Her expertise will be invaluable to Vedere as we advance our lead program toward the clinic.” 

“I am thrilled to join the Vedere team as we work to advance and grow our pipeline of pioneering ocular therapies,” said Dr. Demetriades. “Having spent my entire career in ophthalmology, there continues to be a need for innovative solutions for patients suffering from vision loss. Vedere’s scientific approach has the potential to transform the way we treat eye diseases with the opportunity to not just slow down vision loss, but to restore sight.” 

Prior to joining Vedere, Dr. Demetriades served as the lead clinician for VABYSMOTM (faricimab-svoa) in neovascular age-related macular degeneration at Genentech (a member of the Roche Group), where she played a key role in successfully driving the Phase III clinical program and global regulatory approval process, including the recent FDA (United States) and MHLW (Japan) approvals and regulatory submissions to the EMA (Europe) and Access Consortium. Prior to Genentech, Dr. Demetriades served as Chief of the Glaucoma Service at Weill Cornell Medicine, New York Presbyterian Hospital for five years and as an Assistant Professor of Ophthalmology for ten years. During that time, she also led a research laboratory focused on AAV-mediated neuroprotective gene therapy for glaucoma.

Dr. Demetriades completed her ophthalmology residency at The Wilmer Eye Institute, Johns Hopkins Hospital and her glaucoma clinical fellowship at The Bascom Palmer Eye Institute, University of Miami Miller School of Medicine. She completed a retina research fellowship at The Wilmer Eye Institute, Johns Hopkins Hospital and received her Ph.D. in ocular gene therapy for the treatment of retinal and choroidal neovascularization from the University of Oxford, England. Dr. Demetriades also earned her M.D. and B.A. in Physiological Sciences from the University of Oxford.

About Vedere Bio II, Inc.

Vedere Bio II is a privately held, emerging biopharmaceutical company leveraging proprietary optogenetics and photoswitch technologies along with novel AAV capsids to restore vision in all patients with vision loss due to photoreceptor cell death. Comprised of a diverse team of pioneering scientists and drug developers, Vedere Bio II is discovering and developing next generation ocular therapies to restore and preserve vision for those patients. The company is headquartered in Cambridge, MA and is funded by Atlas Ventures, Octagon Capital, Mission BioCapital, Samsara BioCapital, the RD Fund and Casdin Capital. For more information, please visit www.vederebio.com or follow Vedere Bio II on Twitter and LinkedIn.

CAMBRIDGE, Mass., April 12, 2022 – Vedere Bio II, Inc., a company developing transformative, next-generation therapies for vision restoration and preservation, today announced the appointment of Gina Consylman as Chief Financial Officer. Ms. Consylman is an accomplished life sciences executive with widespread experience in finance, accounting, and investor relations.

“Gina brings extensive financial experience in the biotech and biopharma sectors to Vedere, and we are thrilled to welcome her to the team,” said Cyrus Mozayeni, M.D., Chief Executive Officer & President, Vedere Bio II and Atlas Venture Entrepreneur in Residence. “Her broad public company expertise will be invaluable as we continue to advance our pipeline of pioneering ocular therapies.”

Ms. Consylman brings over 25 years of experience in finance, accounting, investor relations, strategy, and corporate development to Vedere. Before joining Vedere, Ms. Consylman served as CFO of bluebird bio, Inc. where she oversaw financial activities during the company’s transition into two independent entities. Prior to bluebird bio, she spent more than seven years at Ironwood Pharmaceutics, Inc., in roles of increasing responsibilities, culminating in the role of SVP, Chief Financial Officer. There, she was responsible for driving financial strategy through early to late-stage clinical evaluation and commercialization of multiple drug product candidates and products, as well as navigating multiple high-value collaborations with pharmaceutical companies. Ms. Consylman was also Vice President, Corporate Controller and Principal Accounting Officer at Analogic Corporation, where she oversaw the company’s global accounting team. Additionally, she served as Senior Director of Corporate Accounting at Biogen Inc., where she led the accounting teams for the corporate and U.S. commercial business units. Ms. Consylman currently serves on the board of directors for Assembly Biosciences, Inc., and holds a B.S. in accounting from Johnson & Wales University and a M.S. in taxation from Bentley University.

“I’m very excited to have the opportunity to work with the Vedere team to both restore and preserve vision for people suffering from vision loss,” said Gina Consylman. “I look forward to driving Vedere’s financial strategy and maximizing shareholder value by enabling the purposeful advancement of truly transformational science and products.”

About Vedere Bio II, Inc.

Vedere Bio II is a privately held, emerging biopharmaceutical company leveraging proprietary optogenetics and photoswitch technologies along with novel AAV capsids to restore vision in all patients with vision loss due to photoreceptor cell death. Comprising a diverse team of pioneering scientists, Vedere Bio II is discovering and developing next generation ocular gene therapies to increase the quality of vision restoration and preservation for large, underserved indications. The company is headquartered in Cambridge, MA and is funded by Atlas Ventures, Octagon Capital, Mission BioCapital, Samsara BioCapital, the RD Fund and Casdin Capital. For more information, please visit www.vederebio.com or follow Vedere Bio II on Twitter and LinkedIn.

Experienced program executive to lead company’s first optogenetics program into the clinic and guide strategy for the company’s discovery-stage pipeline

CAMBRIDGE, Mass., February 8, 2022 – Vedere Bio II, Inc., a company developing next-generation therapies for vision restoration and preservation in patients with vision loss due to photoreceptor death, today announced the appointment of Martina Schinke, Ph.D., as Vice President, Program Leader. Dr. Schinke will provide strategic leadership to Vedere’s core programs and will be responsible for driving and expanding the company’s pipeline of next-generation ocular therapies.

“With nearly 20 years of experience in program leadership, strategic alliances, and program management, we are thrilled to welcome Martina to Vedere,” said Cyrus Mozayeni, M.D., Chief Executive Officer & President, Vedere Bio II and Atlas Venture Entrepreneur in Residence. “Martina’s expertise leading products from research through clinical development will be essential as we continue to progress our first candidate through IND filing and advance our exciting, discovery-stage pipeline.”

Dr. Schinke joins Vedere Bio II from her role as Vice President, Program Management & Leadership at Finch Therapeutics, where she provided program leadership for the development of a novel class of biological drugs aiming to restore microbiome functionality in Autism Spectrum Disorder and disorders of the gastrointestinal tract. Previously, Dr. Schinke led program management for bluebird bio’s oncology franchise (now 2seventy bio) and co-led development of bluebird’s lead oncology CAR T cell therapy product ABECMA® from research through clinical development in collaboration with Celgene/BMS. Dr. Schinke was formerly with the Novartis Institute for Biomedical Research where she held senior project leadership positions over a nearly 10-year tenure and provided strategic and operational leadership for multiple Novartis early discovery and development programs in several therapeutic areas. Prior to her time at Novartis, she oversaw the microarray facility at the Bauer Center for Genomics Research at Harvard University and was an Instructor in Medicine at Harvard Medical School. Dr. Schinke holds a Ph.D. from Heidelberg University, Germany and completed her postdoctoral training at the Beth Israel Deaconess Medical Center, Harvard Medical School, Boston.

“People with inherited retinal degenerations or dry AMD with geographic atrophy suffer from debilitating vision loss for which currently no treatment options exist,” said Martina Schinke, Ph.D. “I’m excited to help restore vision for these patients and improve their quality of life while also charting the path for Vedere’s innovative products.”

About Vedere Bio II, Inc.

Vedere Bio II is a privately held, emerging biopharmaceutical company leveraging proprietary optogenetics and photoswitch technologies along with novel AAV capsids to restore vision in all patients with vision loss due to photoreceptor cell death. Comprising a diverse team of pioneering scientists, Vedere Bio II is discovering and developing next generation ocular gene therapies to increase the quality of vision restoration and preservation for large, underserved indications. The company is headquartered in Cambridge, MA and is funded by Atlas Ventures, Octagon Capital, Mission BioCapital, Samsara BioCapital, the RD Fund and Casdin Capital. For more information, please visit www.vederebio.com or follow Vedere Bio II on Twitter and LinkedIn.

CAMBRIDGE, Mass., June 22, 2021 – Vedere Bio II, Inc., a company developing next-generation ocular gene therapies for vision restoration and preservation in patients with vision loss due to photoreceptor death, today announced the appointment of Gabor Veres, Ph.D., as Chief Scientific Officer. Dr. Veres will provide strategic leadership to Vedere’s research organization and will be responsible for driving and expanding the company’s pipeline of ocular gene therapies.

“Gabor has over 15 years of experience leading preclinical research and development for international pharmaceutical and biotechnology companies and holds 20 years of experience in the development of cell and gene therapy products,” said Cyrus Mozayeni, M.D., Chief Executive Officer, President of Vedere Bio II and Atlas Venture Entrepreneur in Residence. “His extensive track record designing and executing gene therapy research programs for a range of diseases, including conditions of the eye, will be an incredible asset to our team as we continue our work to restore vision to patients with both genetic and non-genetic causes of vision loss.” 

Dr. Veres joins Vedere Bio II from BioMarin, where he served as Vice President, Head of Gene Therapy Research, focusing on AAV platform discovery and identifying new therapeutic indications in gene therapy. Prior to this role, Dr. Veres was Vice President of Pre-clinical Research at bluebirdbio, where he initiated and coordinated multiple research programs including viral gene delivery to correct genetic and acquired diseases. He also led several projects from pre-clinical research to clinical development including ZYNTEGLOÒ and SKYSONAÔ. Prior to joining bluebirdbio, Dr. Veres served as Vice President of Research and Development at Applied Genetic Technologies Corporation, a gene therapy company focused on developing treatments for rare conditions of the eye, lung and liver. Dr. Veres holds a Ph.D. in Genetics and Biochemistry from the University of Szeged, Hungary.

“Vedere’s approach to vision restoration holds great potential to treat vision loss regardless of underlying genetic cause or disease stage, and I’m looking forward to helping build out and progress the company’s unique platform and product pipeline,” said Gabor Veres, Chief Scientific Officer at Vedere Bio II. “The company’s proprietary AAV capsid technology and mutation agnostic approach move beyond the limitations of traditional gene therapy, with the ultimate goal of restoring vision for patients who have otherwise limited treatment options.”

About Vedere Bio II, Inc.

Vedere Bio II is a privately held, emerging biopharmaceutical company leveraging mutation agnostic technology and novel AAV capsids to restore vision in all patients with vision loss due to photoreceptor cell death. Comprising a diverse team of pioneering scientists, Vedere Bio II is discovering and developing next generation ocular gene therapies to increase the quality of vision restoration and preservation for large, underserved indications. The company is headquartered at LabCentral in Cambridge, MA and is funded by Atlas Ventures, Octagon Capital, Mission BioCapital, Samsara BioCapital, the RD Fund and Casdin Capital. For more information, please visit www.vederebio.com or follow Vedere Bio II on Twitter and LinkedIn.

Uses novel, mutation agnostic optogenetics approach to restore vision in underserved forms of blindness

Company backed by leading life science investors Octagon Capital, Samsara BioCapital and Casdin Capital, along with founding investors Atlas Venture, Mission BioCapital and Foundation Fighting Blindness


CAMBRIDGE, Mass., May 18, 2021 – Vedere Bio II, Inc., a company developing next generation ocular gene therapies designed for vision restoration and preservation for patients with vision loss due to photoreceptor death, today announced the completion of its $77 million Series A financing. Founded by the leadership and research team behind the former Vedere Bio, which was acquired by Novartis in September 2020, Vedere Bio II (Vedere) will leverage its new, proprietary mutation agnostic optogenetics technology to improve upon current gene therapies by restoring functional vision to patients. The financing was led by Octagon Capital, who was also joined by new investors Samsara BioCapital and Casdin Capital, and Vedere’s founding investors, Atlas Venture, Mission BioCapital and the RD Fund, the venture arm of Foundation Fighting Blindness.

“The launch of Vedere Bio II represents a milestone moment in our work to restore vision to patients with both genetic and non-genetic causes of vision loss, and we are excited to work with both our new and founding investors to advance our pipeline,” said Cyrus Mozayeni, M.D., Chief Executive Officer, President of Vedere Bio II and Atlas Venture Entrepreneur in Residence. “Our novel vision restoration approach targets underserved indications and holds great promise to restore lost vision, exceeding the limitations of traditional gene therapy which primarily aim to slow further vision loss.” 

Vedere aims to increase the quality of vision restoration and preservation for all patients with vision loss due to photoreceptor death through delivery of novel payloads via proprietary intravitreally delivered AAV capsids. While most current gene therapies are targeted to specific gene mutations and only slow down vision loss, Vedere’s technology is mutation agnostic and has the potential to rapidly add new function regardless of disease stage. Vedere’s novel approach is anticipated to have several distinct advantages over other optogenetics approaches, which could help patients see stationary and moving objects in both bright and dim settings without the need for a vision-enhancing medical device. The Series A financing will enable Vedere to advance its platform and therapeutic programs (including the lead program to IND filing), attract talent, and invest in research.

“Vedere has a clear mission to restore and preserve vision in patients, and we are excited by the opportunity to partner with and support such a dedicated team with a proven track record of success,” said Ting Jia, Founder and Chief Investment Officer at Octagon Capital. “The company’s unique approach and groundbreaking technology has the potential to address challenges with existing gene therapies that have been unable to be overcome in the past, with the ultimate goal of restoring vision for patients who have limited treatment options.”

Based on technology from the laboratories of Drs. Ehud Isacoff and John G. Flannery of UC Berkeley, and technology directed at enhanced ocular gene therapy delivery arising jointly between UC Berkeley and the School of Veterinary Medicine at the University of Pennsylvania, Vedere Bio II has developed an optogenetics-based platform to develop treatments for inherited retinal diseases (IRDs) and geographic atrophy (GA), unbound by the specific underlying genetic cause. The therapies confer light sensing properties to cells downstream of photoreceptors, which are preserved in most IRDs and GA, therefore rapidly adding new function, regardless of disease stage.

“Vedere’s next generation optogenetic approach aims to make vision restoration and preservation a reality in largely underserved indications,” said Ben Yerxa, Ph.D., CEO of Foundation Fighting Blindness and the RD Fund. “Inherited retinal diseases and geographic atrophy affect over seven million people globally, and all of these patients deserve life-changing therapies. Vedere’s cutting-edge technology has the potential to dramatically expand the number of patients who can be treated for vision loss caused by photoreceptor cell death.”

About Vedere Bio II, Inc.
Vedere Bio II is a privately held, emerging biopharmaceutical company leveraging mutation agnostic technology and novel AAV capsids to restore vision in all patients with vision loss due to photoreceptor cell death. Comprised of a diverse team of pioneering scientists, Vedere Bio II is discovering and developing next generation ocular gene therapies to increase the quality of vision restoration and preservation for large, underserved indications. The company is headquartered at LabCentral in Cambridge, MA and is funded by Atlas Venture, Casdin Capital, Mission BioCapital, Octagon Capital, the RD Fund, and Samsara BioCapital. For more information, please visit www.vederebio.com or follow Vedere Bio II on Twitter and LinkedIn.